The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters
Identifieur interne : 001E96 ( Main/Exploration ); précédent : 001E95; suivant : 001E97The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters
Auteurs : Emmie De Wit [États-Unis] ; Joseph Prescott [États-Unis] ; Laura Baseler [États-Unis] ; Trenton Bushmaker [États-Unis] ; Tina Thomas [États-Unis] ; Matthew G. Lackemeyer [États-Unis] ; Cynthia Martellaro [États-Unis] ; Shauna Milne-Price [États-Unis] ; Elaine Haddock [États-Unis] ; Bart L. Haagmans [Pays-Bas] ; Heinz Feldmann [États-Unis, Canada] ; Vincent J. Munster [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus (physiologie), Cricetinae, Dipeptidyl peptidase 4 (métabolisme), Humains, Immunohistochimie, Infections de l'appareil respiratoire (virologie), Infections à coronavirus (virologie), Interactions hôte-pathogène, Mesocricetus (métabolisme), Mesocricetus (virologie), Modèles animaux de maladie humaine, Moyen Orient, Poids du corps (physiologie), Réplication virale (physiologie), Syndrome, Température du corps (physiologie).
- MESH :
- métabolisme : Dipeptidyl peptidase 4, Mesocricetus.
- physiologie : Coronavirus, Poids du corps, Réplication virale, Température du corps.
- virologie : Infections de l'appareil respiratoire, Infections à coronavirus, Mesocricetus.
- Animaux, Cricetinae, Humains, Immunohistochimie, Interactions hôte-pathogène, Modèles animaux de maladie humaine, Moyen Orient, Syndrome.
English descriptors
- KwdEn :
- Animals, Body Temperature (physiology), Body Weight (physiology), Coronavirus (physiology), Coronavirus Infections (virology), Cricetinae, Dipeptidyl Peptidase 4 (metabolism), Disease Models, Animal, Host-Pathogen Interactions, Humans, Immunohistochemistry, Mesocricetus (metabolism), Mesocricetus (virology), Middle East, Respiratory Tract Infections (virology), Syndrome, Virus Replication (physiology).
- MESH :
- chemical , metabolism : Dipeptidyl Peptidase 4.
- geographic : Middle East.
- metabolism : Mesocricetus.
- physiology : Body Temperature, Body Weight, Coronavirus, Virus Replication.
- virology : Coronavirus Infections, Mesocricetus, Respiratory Tract Infections.
- Animals, Cricetinae, Disease Models, Animal, Host-Pathogen Interactions, Humans, Immunohistochemistry, Syndrome.
Abstract
In 2012 a novel coronavirus, MERS-CoV, associated with severe respiratory disease emerged in the Arabian Peninsula. To date, 55 human cases have been reported, including 31 fatal cases. Several of the cases were likely a result of human-to-human transmission. The emergence of this novel coronavirus prompts the need for a small animal model to study the pathogenesis of this virus and to test the efficacy of potential intervention strategies. In this study we explored the use of Syrian hamsters as a small animal disease model, using intratracheal inoculation and inoculation via aerosol. Clinical signs of disease, virus replication, histological lesions, cytokine upregulation nor seroconversion were observed in any of the inoculated animals, indicating that MERS-CoV does not replicate in Syrian hamsters.
Url:
DOI: 10.1371/journal.pone.0069127
PubMed: 23844250
PubMed Central: 3699510
Affiliations:
- Canada, Pays-Bas, États-Unis
- Hollande-Méridionale, Manitoba, Maryland, Montana
- Rotterdam, Winnipeg
- Université du Manitoba
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Le document en format XML
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Coronavirus (physiologie)</term>
<term>Cricetinae</term>
<term>Dipeptidyl peptidase 4 (métabolisme)</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Infections de l'appareil respiratoire (virologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Interactions hôte-pathogène</term>
<term>Mesocricetus (métabolisme)</term>
<term>Mesocricetus (virologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Moyen Orient</term>
<term>Poids du corps (physiologie)</term>
<term>Réplication virale (physiologie)</term>
<term>Syndrome</term>
<term>Température du corps (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Middle East</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mesocricetus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dipeptidyl peptidase 4</term>
<term>Mesocricetus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term>
<term>Poids du corps</term>
<term>Réplication virale</term>
<term>Température du corps</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Body Temperature</term>
<term>Body Weight</term>
<term>Coronavirus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
<term>Infections à coronavirus</term>
<term>Mesocricetus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Mesocricetus</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Host-Pathogen Interactions</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cricetinae</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Interactions hôte-pathogène</term>
<term>Modèles animaux de maladie humaine</term>
<term>Moyen Orient</term>
<term>Syndrome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>In 2012 a novel coronavirus, MERS-CoV, associated with severe respiratory disease emerged in the Arabian Peninsula. To date, 55 human cases have been reported, including 31 fatal cases. Several of the cases were likely a result of human-to-human transmission. The emergence of this novel coronavirus prompts the need for a small animal model to study the pathogenesis of this virus and to test the efficacy of potential intervention strategies. In this study we explored the use of Syrian hamsters as a small animal disease model, using intratracheal inoculation and inoculation via aerosol. Clinical signs of disease, virus replication, histological lesions, cytokine upregulation nor seroconversion were observed in any of the inoculated animals, indicating that MERS-CoV does not replicate in Syrian hamsters. </p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name>
</author>
<author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name>
</author>
<author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A Annan</name>
</author>
<author><name sortKey="Baldwin, Hj" uniqKey="Baldwin H">HJ Baldwin</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Klose, Sm" uniqKey="Klose S">SM Klose</name>
</author>
<author><name sortKey="Owusu, M" uniqKey="Owusu M">M Owusu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Ojeda Flores, R" uniqKey="Ojeda Flores R">R Ojeda-Flores</name>
</author>
<author><name sortKey="Rico Chavez, O" uniqKey="Rico Chavez O">O Rico-Chavez</name>
</author>
<author><name sortKey="Navarette Macias, I" uniqKey="Navarette Macias I">I Navarette-Macias</name>
</author>
<author><name sortKey="Zambrana Torrelio, Cm" uniqKey="Zambrana Torrelio C">CM Zambrana-Torrelio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Kallies, S" uniqKey="Kallies S">S Kallies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Stohr, K" uniqKey="Stohr K">K Stohr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name>
</author>
<author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name>
</author>
<author><name sortKey="Guarner, J" uniqKey="Guarner J">J Guarner</name>
</author>
<author><name sortKey="Hayes, N" uniqKey="Hayes N">N Hayes</name>
</author>
<author><name sortKey="Murphy, B" uniqKey="Murphy B">B Murphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name>
</author>
<author><name sortKey="Lamirande, Ew" uniqKey="Lamirande E">EW Lamirande</name>
</author>
<author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name>
</author>
<author><name sortKey="Jackson, Jp" uniqKey="Jackson J">JP Jackson</name>
</author>
<author><name sortKey="Paddock, Cd" uniqKey="Paddock C">CD Paddock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hartings, Jm" uniqKey="Hartings J">JM Hartings</name>
</author>
<author><name sortKey="Roy, Cj" uniqKey="Roy C">CJ Roy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alexander, Dj" uniqKey="Alexander D">DJ Alexander</name>
</author>
<author><name sortKey="Collins, Cj" uniqKey="Collins C">CJ Collins</name>
</author>
<author><name sortKey="Coombs, Dw" uniqKey="Coombs D">DW Coombs</name>
</author>
<author><name sortKey="Gilkison, Is" uniqKey="Gilkison I">IS Gilkison</name>
</author>
<author><name sortKey="Hardy, Cj" uniqKey="Hardy C">CJ Hardy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Eckerle, I" uniqKey="Eckerle I">I Eckerle</name>
</author>
<author><name sortKey="Bleicker, T" uniqKey="Bleicker T">T Bleicker</name>
</author>
<author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name>
</author>
<author><name sortKey="Landt, O" uniqKey="Landt O">O Landt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zivcec, M" uniqKey="Zivcec M">M Zivcec</name>
</author>
<author><name sortKey="Safronetz, D" uniqKey="Safronetz D">D Safronetz</name>
</author>
<author><name sortKey="Haddock, E" uniqKey="Haddock E">E Haddock</name>
</author>
<author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name>
</author>
<author><name sortKey="Ebihara, H" uniqKey="Ebihara H">H Ebihara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haller, O" uniqKey="Haller O">O Haller</name>
</author>
<author><name sortKey="Stertz, S" uniqKey="Stertz S">S Stertz</name>
</author>
<author><name sortKey="Kochs, G" uniqKey="Kochs G">G Kochs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name>
</author>
<author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name>
</author>
<author><name sortKey="Dekkers, Dh" uniqKey="Dekkers D">DH Dekkers</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Hollande-Méridionale</li>
<li>Manitoba</li>
<li>Maryland</li>
<li>Montana</li>
</region>
<settlement><li>Rotterdam</li>
<li>Winnipeg</li>
</settlement>
<orgName><li>Université du Manitoba</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Montana"><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name>
</region>
<name sortKey="Baseler, Laura" sort="Baseler, Laura" uniqKey="Baseler L" first="Laura" last="Baseler">Laura Baseler</name>
<name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name>
<name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name>
<name sortKey="Haddock, Elaine" sort="Haddock, Elaine" uniqKey="Haddock E" first="Elaine" last="Haddock">Elaine Haddock</name>
<name sortKey="Lackemeyer, Matthew G" sort="Lackemeyer, Matthew G" uniqKey="Lackemeyer M" first="Matthew G." last="Lackemeyer">Matthew G. Lackemeyer</name>
<name sortKey="Martellaro, Cynthia" sort="Martellaro, Cynthia" uniqKey="Martellaro C" first="Cynthia" last="Martellaro">Cynthia Martellaro</name>
<name sortKey="Milne Price, Shauna" sort="Milne Price, Shauna" uniqKey="Milne Price S" first="Shauna" last="Milne-Price">Shauna Milne-Price</name>
<name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name>
<name sortKey="Prescott, Joseph" sort="Prescott, Joseph" uniqKey="Prescott J" first="Joseph" last="Prescott">Joseph Prescott</name>
<name sortKey="Thomas, Tina" sort="Thomas, Tina" uniqKey="Thomas T" first="Tina" last="Thomas">Tina Thomas</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
</region>
</country>
<country name="Canada"><region name="Manitoba"><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name>
</region>
</country>
</tree>
</affiliations>
</record>
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